| Yazarlar (6) |
Erdinç Türk
Hatay Mustafa Kemal Üniversitesi, Türkiye |
|
Fatih Mehmet Kandemir
Atatürk Üniversitesi, Türkiye |
|
Serkan Yıldırım
Atatürk Üniversitesi, Türkiye |
|
Cüneyt Çağlayan
Bingöl Üniversitesi, Türkiye |
|
Sefa Küçükler
Türkiye |
Prof. Dr. Müslüm KUZU
Ağrı İbrahim Çeçen Üniversitesi, Türkiye |
| Özet |
| The present study was conducted to investigate the protective effects of hesperidin (HSP) against sodium arsenite (SA)-induced nephrotoxicity and hepatotoxicity in rats. Thirty-five male Sprague Dawley rats were divided into five groups as follows: control, HSP, SA, SA + HSP 100, and SA + HSP 200. Rats were orally gavaged with SA (10 mg/kg body weight) and HSP (100 and 200 mg/kg body weight) for 15 days. SA increased oxidative damage by decreasing antioxidant enzyme activities, such as catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx), and glutathione (GSH) level and increasing malondialdehyde (MDA) level in the kidney and liver tissues. In addition, it increased serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities and serum urea and creatinine levels. Furthermore, SA caused inflammation, apoptosis, and oxidative DNA damage by increasing tumor necrosis factor-α (TNF-α), nuclear factor kappa B (NF-κB), interleukin-1β (IL-1β), cysteine aspartate-specific protease-3 (caspase-3), and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels in the kidney and liver tissues and by increasing liver p53 and kidney interleukin-6 (IL-6) expressions. In other words, HSP administration reduced apoptosis, oxidative stress, inflammation, and oxidative DNA damage significantly in SA-induced kidney and liver tissues depending on dose. In this study, it was seen that HSP showed a protective effect against SA-induced kidney and liver toxicity. |
| Anahtar Kelimeler |
| Apoptosis | Hepatotoxicity | Hesperidin | Inflammation | Nephrotoxicity | Sodium arsenite |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | BIOLOGICAL TRACE ELEMENT RESEARCH |
| Dergi ISSN | 0163-4984 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 05-2019 |
| Cilt No | 189 |
| Sayı | 1 |
| Sayfalar | 95 / 108 |
| Doi Numarası | 10.1007/s12011-018-1443-6 |
| Makale Linki | http://link.springer.com/10.1007/s12011-018-1443-6 |
| Atıf Sayıları | |
| WoS | 104 |
| Google Scholar | 146 |
