| Yazarlar (7) |
Erdinç Türk
Hatay Mustafa Kemal Üniversitesi, Türkiye |
|
Mehmet Güvenç
Hatay Mustafa Kemal Üniversitesi, Türkiye |
|
Mustafa Cellat
Hatay Mustafa Kemal Üniversitesi, Türkiye |
|
Ahmet Uyar
Hatay Mustafa Kemal Üniversitesi, Türkiye |
Prof. Dr. Müslüm KUZU
Karabük Üniversitesi, Türkiye |
|
Ahmet Gökhan Ağgül
Ağrı İbrahim Çeçen Üniversitesi, Türkiye |
|
Akın Kırbaş
Yozgat Bozok Üniversitesi, Türkiye |
| Özet |
| The clinical use of drugs used in the treatment of diseases is limited due to the toxic side effects, and many studies have been conducted to benefit from herbal adjuvant therapies recently to eliminate these effects. In this study, the protective effect of zingerone against liver and kidney damage generated in rats through methotrexate (MTX). Histopathological investigations were performed to determine tissue damage caused by MTX and the healing effect of zingone and liver function markers such as serum alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), and renal function markers such as urea, creatine, and aquaporin-1 (AQP-1) were measured. The effects of MTX and protective properties of zingerone on oxidative stress were investigated through the measurement of malondialdehyde and reduced glutathione (GSH) levels, catalase (CAT), and glutathione peroxidase (GPx) enzyme activities. The anti-inflammatory effect of zingerone was determined by measuring the cytokine levels causing inflammation such as nuclear factor-kappa B (NF-κB), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β), and its effects on apoptosis were determined by immunohistochemical analysis of caspase-3 and B-cell lymphoma-2 (Bcl-2) expression levels. According to the results obtained within the scope of the study, it was determined that zingerone treatment prevented the increase in MTX-induced liver and kidney function markers, showed healing effects on antioxidant parameters degraded in both tissues, and decreased the inflammation parameters. It was determined that it also prevented apoptosis and possessed a protective effect on disrupted tissue architecture by decreasing the increased caspase-3 expression and increasing the decreased Bcl-2 level. |
| Anahtar Kelimeler |
| Methotrexate | apoptosis | inflammation | oxidative stress | zingerone |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | DRUG AND CHEMICAL TOXICOLOGY |
| Dergi ISSN | 0148-0545 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 05-2022 |
| Cilt No | 45 |
| Sayı | 3 |
| Sayfalar | 1054 / 1065 |
| Doi Numarası | 10.1080/01480545.2020.1804397 |
| Makale Linki | http://dx.doi.org/10.1080/01480545.2020.1804397 |
| Atıf Sayıları | |
| WoS | 30 |
| Google Scholar | 41 |
