| Yazarlar (10) |
Ahmet Özkaya
Adıyaman Üniversitesi, Türkiye |
|
Zafer Şahin
Necmettin Erbakan Üniversitesi, Türkiye |
Prof. Dr. Müslüm KUZU
Ağrı İbrahim Çeçen Üniversitesi, Türkiye |
|
Yavuz Selim Saglam
Türkiye |
|
Mustafa Ozkaraca
Türkiye |
|
Mirac Uckun
Türkiye |
|
Ertan Yologlu
Türkiye |
|
Veysal Çomaklı
Ağrı İbrahim Çeçen Üniversitesi, Türkiye |
|
Ramazan Demirdağ
Ağrı İbrahim Çeçen Üniversitesi, Türkiye |
|
Semra Yoloğlu
Türkiye |
| Özet |
| In this study, the effect of geraniol (50 mg/kg for 30 d), a natural antioxidant and repellent/antifeedant monoterpene, in a rat model of lead acetate-induced (500 ppm for 30 d) liver damage was evaluated. Hepatic malondialdehyde increased in the lead acetate group. Reduced glutathione unchanged, but glutathione S-transferase, glutathione reductase, as well as carboxylesterase activities decreased in geraniol, lead acetate and geraniol + lead acetate groups. 8-OhDG immunoreactivity, mononuclear cell infiltrations and hepatic lead concentration were lower in the geraniol + lead acetate group than the lead acetate group. Serum aspartate aminotransferase and alanine aminotransferase activities increased in the Pb acetate group. In conclusion, lead acetate causes oxidative and toxic damage in the liver and this effect can reduce with geraniol treatment. However, we first observed that lead acetate, as well as geraniol, can affect liver carboxylesterase activity. |
| Anahtar Kelimeler |
| Geraniol | carboxylesterase | lead acetate | liver | oxidative stress |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY |
| Dergi ISSN | 1381-3455 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2018 |
| Cilt No | 124 |
| Sayı | 1 |
| Sayfalar | 80 / 87 |
| Doi Numarası | 10.1080/13813455.2017.1364772 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/13813455.2017.1364772 |
| Atıf Sayıları | |
| WoS | 21 |
| Google Scholar | 35 |
