| Yazarlar (8) |
Nihal Yiğitbaşı
|
|
Leman Melis Yurdum
|
Doç. Dr. Ümit YILMAZ
İnönü Üniversitesi, Türkiye |
Doç. Dr. Nesibe YILMAZ
İnönü Üniversitesi, Türkiye |
|
Bedia Çakmakoğlu
İstanbul Üniversitesi, Türkiye |
|
Hülya Yılmaz Aydoğan
İstanbul Üniversitesi, Türkiye |
|
Kubilay Karşıdağ
İstanbul Üniversitesi, Türkiye |
|
Şakir Ümit Zeybek
İstanbul Üniversitesi, Türkiye |
| Özet |
| Increased oxidative stress in type 2 diabetes cause to the accumulation of DNA damage and results diabetic complications. Xeroderma pigmentosum complementation group D (XPD) and human oxoguanine glycosylase 1 (hOGG1) are genes involved in the repair of oxidative DNA damage. In this study, we aimed to evaluate association between XPD Lys751Gln and hOGG1 Ser326Cys polymorphisms with type 2 diabetes mellitus (T2DM) in the Turkish population. Seventy-one T2DM patients and 54 healthy individuals were incorporated into this study. DNA was extracted from whole blood. The Polymerase Chain Reaction (PCR)-Restriction Fragment Length Polymorphism (RFLP) techniques were used. There was statistically significant difference between patient and control groups in the genotype distribution of XPD Lys751Gln polymorphism (p˂0.05). While the Lys/Lys genotype was found significantly higher in control group, the Lys/Gln was higher in patients. (p˂0.05). There was no significant difference between groups in the genotype distribution of hOGG1 Ser326Cys polymorphism. Despite the small number of subjects included in the study, it could be interpreted that the Lys/Gln genotype of XPD Lys751Gln polymorphism may be contributing to the development of diabetes. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayımlanan tam makale |
| Dergi Adı | Medicine Science |
| Dergi ISSN | 2147-0634 |
| Dergi Tarandığı Indeksler | TR DİZİN |
| Makale Dili | İngilizce |
| Basım Tarihi | 06-2018 |
| Cilt No | 7 |
| Sayı | 2 |
| Sayfalar | 326 / 329 |
| Doi Numarası | 10.5455/medscience.2017.06.8704 |
| Makale Linki | file:///C:/Users/User/Downloads/1209842_1741173718.pdf |
| Atıf Sayıları |
