| Yazarlar (7) |
Dr. Öğr. Üyesi Mehmet DEMİR
Karabük Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Ümit YILMAZ
İnönü Üniversitesi, Türkiye |
Cemil Çolak
İnönü Üniversitesi, Türkiye |
|
Yılmaz Çiğremiş
İnönü Üniversitesi, Türkiye |
|
Fatma Özyalın
|
|
İbrahim Tekedereli
İnönü Üniversitesi, Türkiye |
|
Süleyman Sandal
İnönü Üniversitesi, Türkiye |
| Özet |
| Alzheimer's disease (AD) is a progressive neurodegenerative disease. This study was performed to determine the possible relationship between melatonin, which is known to play a role in the neuro-protective mechanism in AD, and fasciculation and elongation protein zeta 1 (FEZ1). Thirty male rats were included and separated into 3 groups (n = 10) as vehicle (artificial cerebrospinal fluid), streptozotocin (STZ) and STZ+melatonin (MLT). Two intracerebroventricular (icv) injections of 3 mg/kg STZ were made 48 hours apart. MLT injections were implemented for 14 days (ip; 10mg/kg/day). The Morris Water Maze (MWM) test was performed and rats were sacrificed to assess FEZ1 gene expression and protein levels from the hippocampus tissues and serum levels of noradrenaline (NA), dopamine and serotonin were determined from the blood samples. It was determined that the FEZ1/β-actin protein ratio in the STZ group was significantly higher than that of the Vehicle group (p < 0.05) and in the MLT‑administered group, the protein levels were decreased to the levels observed in the Vehicle group. Serum NA levels of STZ and STZ+MLT groups were found to be lower than those in the Vehicle group, while no difference was found regarding dopamine and serotonin levels. These findings show that reversal of increased FEZ1 levels in AD-induced rats with melatonin administration is the evidence of the effect of melatonin through FEZ1 in AD (Tab. 2, Fig. 5, Ref. 67). Keywords: FEZ1, Alzheimer's disease, melatonin, rat, microtubules, mitochondria. |
| Anahtar Kelimeler |
| FEZ1 | Alzheimer's disease | melatonin | rat | microtubules | mitochondria |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Bratislava Medical Journal-Bratislavske Lekarske Listy |
| Dergi ISSN | 0006-9248 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2019 |
| Cilt No | 120 |
| Sayı | 1 |
| Sayfalar | 70 / 77 |
| Doi Numarası | 10.4149/BLL_2019_011 |
| Makale Linki | http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=6005&category_id=146&filter[journal]=&filter[year]=&filter[issue]=&option=com_virtuemart&Itemid=1 |
| Atıf Sayıları | |
| WoS | 5 |
