Phosphorus nitrogen compounds Part 28 Syntheses structuralcharacterizations antimicrobial and cytotoxic activities and DNAinteractions of new phosphazenes bearing vanillinato and pendantferrocenyl groups
Yazarlar (11)
Doç. Dr. Yasemin TÜMER Karabük Üniversitesi, Türkiye
Prof. Dr. Nuran Asmafiliz Ankara Üniversitesi, Türkiye
Zeynel Kílíc Ankara Üniversitesi, Türkiye
Tuncer Hökelek
Hacettepe Üniversitesi, Türkiye
Hacettepe Üniversitesi, Türkiye
L. Yasemin Koç Ankara Üniversitesi, Türkiye
Leyla Açík Gazi Üniversitesi, Türkiye
Prof. Dr. Mehmet Lütfi Yola Sinop Üniversitesi, Türkiye
Prof. Dr. Ali Osman Solak Ankara Üniversitesi, Türkiye
Yaǧmur Öner Gazi Üniversitesi, Türkiye
Devrim Dündar Kocaeli Üniversitesi, Türkiye
Makbule Yavuz Kocaeli Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Molecular Structure (Q3) | ||
| Dergi ISSN | 0022-2860 Dergi Bilgileri (2013) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2013 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-10-2013 |
| Cilt / Sayı / Sayfa | 1049 / 1 / 112–124 | DOI | 10.1016/j.molstruc.2013.06.036 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0022286013005565 | ||
| UAK Araştırma Alanları |
Anorganik Kimya
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| Özet |
| The gradually Cl replacement reactions of spirocyclic mono (1 and 2) and bisferrocenyl cyclotriphosphazenes (3-5) with the potassium salt of 4-hydroxy-3-methoxybenzaldehyde (potassium vanillinate) gavemono (1a- 5a), geminal (gem-1b-5b), non-geminal (cis-1b, cis-5b and trans-2b-5b), tri (1c-5c) and tetra-substituted phosphazenes (1d-5d). Some phosphazenes have stereogenic P-center(s). The chirality of 4c was verified using chiral HPLC column. Electrochemical behaviors were influenced only by the number of ferrocene groups, but not the length of the amine chains and the substituent(s). The structures of the new phosphazenes were determined by FTIR, MS, 1H, 13Cand31PNMR,HSQC andHMBC spectral data. The solid-state structures of cis-1b and 4d were examined by single crystal X-ray diffraction techniques. The twelve phosphazene derivatives were screened for antimicrobial activity and the compounds 5a, cis-1b and 2c exhibited the highest antibacterial activity against G(+) and G(-) bacteria. In addition, it was found that overall gem-1b inhibited the growth of Mycobacterium tuberculosis. The compounds 1d, 2d and 4d were tested in HeLa cancer cell lines. Among these compounds, 2d had cytotoxic effect on HeLa cell in the first 48 h.Moreover, interactions between compounds 2a, gem-1b, gem-2b, cis-1b, 2c, 3c, 4c, 5c, 1d, 2d and 4d, and pBR322 plasmid DNA were investigated. © 2013 Elsevier B.V. All rights reserved. |
| Anahtar Kelimeler |
| Antituberculosis activity | Crystal structure | Electrochemistry | Ferrocenylphosphazenes | HeLa cell line | Spectroscopy |
Science Direct
Phosphorus nitrogen compounds Part 28 Syntheses structuralcharacterizations antimicrobial and cytotoxic activities and DNAinteractions of new phosphazenes bearing vanillinato and pendantferrocenyl groups
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 52 |
| Scopus | 53 |