Phosphorus nitrogen compounds part 30 Syntheses and structural investigations antimicrobial and cytotoxic activities and DNA interactions of vanillinato substituted NN or NO spirocyclic monoferrocenyl cyclotriphosphazenes
 
Yazarlar (9)
Doç. Dr. Yasemin TÜMER Karabük Üniversitesi, Türkiye
L. Yasemin Koç
Ankara Üniversitesi, Türkiye
Prof. Dr. Nuran Asmafiliz Ankara Üniversitesi, Türkiye
Öğr. Gör. Zeynel Kılıç Ankara Üniversitesi, Türkiye
Tuncer Hökelek
Hacettepe Üniversitesi, Türkiye
Hossien Soltanzade Gazi Üniversitesi, Türkiye
Prof. Dr. Leyla Açık Gazi Üniversitesi, Türkiye
Mehmet Lütfi Yola Sinop Üniversitesi, Türkiye
Prof. Dr. Ali Osman Solak Kyrgyz-Turkish Manas University, Türkiye
Makale Türü Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı Journal of Biological Inorganic Chemistry (Q2)
Dergi ISSN 0949-8257 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce Basım Tarihi 01-2015
Kabul Tarihi Yayınlanma Tarihi 10-12-2014
Cilt / Sayı / Sayfa 20 / 1 / 165–178 DOI 10.1007/s00775-014-1223-5
Makale Linki http://link.springer.com/10.1007/s00775-014-1223-5
UAK Araştırma Alanları
Anorganik Kimya
Özet
The gradual Cl replacement reactions of NN (1–3) or NO spirocyclic monoferrocenyl cyclotriphosphazenes (4 and 5) with the potassium salt of 4-hydroxy-3-methoxybenzaldehyde (potassium vanillinate) resulted in the mono (1a–5a), geminal (gem-1b–5b), non-geminal (cis-5b and trans-1b–4b), tri (1c, 3c–5c) and tetra-vanillinato-substituted phosphazenes (1d–5d). All the phosphazene derivatives have stereogenic P-center(s), except tetra-substituted ones. The vanillinatophosphazenes have reversible voltammograms with one-electron anodic and cathodic peaks which are attributed to ferrocenyl redox probe. The structures of the new phosphazene compounds were determined by FTIR, MS, 1H, 13C{1H} and 31P{1H} NMR spectral data. The solid-state structure of cis-5b was examined by single-crystal X-ray diffraction techniques. In addition, the compounds were tested in HeLa cancer cell lines using MTT assay …
Anahtar Kelimeler
Antimicrobial activity | Cytotoxicity | DNA interaction | Ferrocenylphosphazenes | Spectroscopy