| Yazarlar (6) |
Ahmet Gökhan Ağgül
Ağrı İbrahim Çeçen Üniversitesi, Türkiye |
|
Parham Taslımı
Türkiye |
Prof. Dr. Müslüm KUZU
Karabük Üniversitesi, Türkiye |
|
Naim Uzun
Ağrı İbrahim Çeçen Üniversitesi, Türkiye |
|
Sinan Bilginer
Türkiye |
|
İlhami Gülçin
Atatürk Üniversitesi, Türkiye |
| Özet |
| Recently, carbonic anhydrase (CA, E.C.4.2.1.1) inhibitors from natural product have paved the way for novel drug design in the treatment and prevention of some global diseases such as glaucoma, diabetes, and cancer. For this purpose, the inhibition effects of oleuropein and verbascoside from olive (Olea europaea L.) oil on human carbonic anhydrase I, and II (hCA I, and II) isoenzymes were evaluated in the current study. The inhibition effects of both natural compounds were determined by the esterase activity (in vitro). IC value of oleuropein and verbascoside was calculated as 1.57 and 1.73 µM for hCA I isoenzyme, respectively. At the same manner, K values were determined as 1.25 ± 0.42 and 2.00 ± 0.42 µM, respectively. Then, IC value of each compound for hCA II isoenzyme was calculated as 2.23 and 1.90 µM, respectively. Similarly, K values were determined as 2.37 ± 0.87 µM and 1.49 ± 0.33 µM, respectively. Also, the inhibitory effects and potent binding mechanisms of oleuropein and verbascoside on hCA I, and II isoenzymes were realized by molecular docking studies. Consequently, both natural phenolic compounds demonstrated the potent inhibition profiles against the both isoenzymes. Therefore, we believe that these results may break new ground in the drug development for the treatment of some global disorders. |
| Anahtar Kelimeler |
| carbonic anhydrase | enzyme inhibition | molecular docking | oleuropein | verbascoside |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | JOURNAL OF OLEO SCIENCE |
| Dergi ISSN | 1345-8957 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | Türkçe |
| Basım Tarihi | 01-2021 |
| Cilt No | 70 |
| Sayı | 9 |
| Sayfalar | 1275 / 1283 |
| Doi Numarası | 10.5650/jos.ess21106 |
| Makale Linki | http://dx.doi.org/10.5650/jos.ess21106 |
| Atıf Sayıları | |
| WoS | 16 |
| Google Scholar | 18 |
