| Yazarlar (5) |
Fatma Gülruy Aydın
Türkiye |
|
Zeynep Aleyna Kahraman
Türkiye |
|
Emir Alper Türkoğlu
Sağlık Bilimleri Üniversitesi, Türkiye |
Prof. Dr. Müslüm KUZU
Karabük Üniversitesi, Türkiye |
|
Zeki Severoğlu
Türkiye |
| Özet |
| Carbonic anhydrases (CAs; EC 4.2.1.1) are essential family of metalloenzymes which catalyze the interconversion between carbon dioxide (CO2) and bicarbonate (HCO3-) in all organisms of three-domains of life. Huge amounts of attempts related to catalytic activity of CAs have been widely expanded to treat many clinical diseases. This study aimed to determine in-vitro antioxidant activities and human CA I (hCA I) and II (hCA II) inhibitory properties of Ferula communis extracts. Among all extracts of F. communis, the hexane extract has showed the best inhibitory profile on hCA I and II with IC50 values 8.68 µg/mL and 28 µg/mL and Ki values 2.026 µg/mL and 11.6 µg/mL, respectively. All extracts showed mild to moderate antioxidant activity. According to the results of DPPH assay, ethanol-water extract showed the highest activity with IC50: 0.1128±0.0066 value. Chloroform extract showed the highest activity on CUPRAC assay with the value of 1.305±0.037 mM Trolox equivalent/mg extract. However, further analytical, in-vivo and clinical studies are needed to confirm the activities of F. communis. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayımlanan tam makale |
| Dergi Adı | International Journal of Agriculture, Environment and Food Sciences |
| Dergi ISSN | 2602-246X |
| Dergi Tarandığı Indeksler | TR DİZİN |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2021 |
| Cilt No | 5 |
| Sayı | 4 |
| Sayfalar | 592 / 599 |
| Doi Numarası | 10.31015/jaefs.2021.4.19 |
| Makale Linki | http://dx.doi.org/10.31015/jaefs.2021.4.19 |
| Atıf Sayıları | |
| TRDizin | 1 |
| Google Scholar | 6 |
