Some phenolic natural compounds as carbonic anhydrase inhibitors: An in vitro and in silico study
Yazarlar (5)
Ağrı İbrahim Çeçen Üniversitesi, Türkiye
Ağrı İbrahim Çeçen Üniversitesi, Türkiye
Prof. Dr. Müslüm KUZU
Karabük Üniversitesi, Türkiye
Bartın Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Archiv Der Pharmazie |
| Dergi ISSN | 0365-6233 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | Türkçe |
| Basım Tarihi | 06-2022 |
| Cilt No | 355 |
| Sayı | 6 |
| DOI Numarası | 10.1002/ardp.202100476 |
| Makale Linki | http://dx.doi.org/10.1002/ardp.202100476 |
| Özet |
| This paper presents experimental and molecular docking studies on the inhibitory effects of tyrosol, hydroxytyrosol, luteolin, diosmetin, caffeic acid, luteolin 7-O-glycoside, and apigenin 7-O-glycoside from olive (Olea europaea L.) leaf against human carbonic anhydrase (hCA, E.C.4.2.1.1) isozymes I and II. After these isozymes were separately purified, their activities were determined using the esterase activity. IC values for hCA I and II were calculated as 2.02-11.38 µM and 2.23-9.05 µM, respectively. The compounds were identified as CA inhibitors, with K values in the ranges of 1.66-9.17 µM for the hCA I isozyme and 1.49-14.21 µM for hCA II. The inhibitory effects of these natural compounds were also compared to acetazolamide, which is a potent inhibitor of both CA isozymes. Our results may contribute to the synthesis of new CA inhibitors and pave the way for new drug design in the treatment of a number of diseases including cancer, obesity, diabetes, and glaucoma. |
| Anahtar Kelimeler |
| carbonic anhydrase | enzyme inhibition | molecular docking | olive leaf | phenolic compound |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 21 |
| SCOPUS | 20 |
| Google Scholar | 25 |