| Yazarlar (8) |
Mohammed Raed Abdullah Al Gburi
|
Prof. Dr. Eyüp ALTINÖZ
Karabük Üniversitesi, Türkiye |
|
Hülya Elbe
Muğla Sıtkı Koçman Üniversitesi, Türkiye |
|
Melike Özgül Önal
Türkiye |
Dr. Öğr. Üyesi Ümit YILMAZ
Karabük Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Nesibe YILMAZ
Karabük Üniversitesi, Türkiye |
|
Melike Karayakalı
|
Dr. Öğr. Üyesi Mehmet DEMİR
Karabük Üniversitesi, Türkiye |
| Özet |
| We aimed to observe the possible effects of melatonin (MLT) deprivation (pinealectomy) and exogenous MLT administration on pulmonary edema induced by alpha-naphthylthiourea (ANTU), a toxic chemical agent, in rats. Seventy animals were assigned to seven groups: control, sham pinealectomy (PINX), PINX, ANTU (10 mg/kg intraperitoneal on day 30), ANTU + MLT (10 mg/kg/day i.p. for 30 days), ANTU + PINX, and ANTU + PINX + MLT.In this study, pleural effusion (PE) formation, lung weight/body weight (LW/BW) and PE/BW ratios (fluid accumulation and weight values in the lungs) increase detected. Pre-ANTU MLT administration led to significant decreases in PE, LW/BW, and PE/BW levels. The inhibited glutathione (GSH) and superoxide dismutase (SOD) levels and high malondialdehyde (MDA) levels that ANTU increase lipid peroxidation in the study. MLT administration eliminated oxidative stress by reducing MDA and ameliorating GSH and SOD levels.Pre-ANTU MLT administration led to a significant decrease in interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) levels in the lung when compared to the ANTU group without MLT administration. Post-pinealectomy ANTU administration significantly increased IL-1β and TNF-α levels when compared to ANTU and MLT administration without pinealectomy. Diffused inflammatory cell infiltration, interstitial pulmonary edema, and histopathological congestion were observed after the administration of ANTU. Severity of the damage was elevated in the ANTU + PINX group. MLT treatment regressed pulmonary effusion and edema and improves lung structure. In brief, the findings suggested that MLT inhibited proinflammatory mediators and could serve as a therapeutic agent to prevent inflammatory disorders. |
| Anahtar Kelimeler |
| Alpha-naphthylthiourea | melatonin | oxidative stress | pinealectomy | pulmonary edema | rat |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Drug and Chemical Toxicology |
| Dergi ISSN | 0148-0545 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2023 |
| Cilt No | 46 |
| Sayı | 5 |
| Sayfalar | 1024 / 1034 |
| Doi Numarası | 10.1080/01480545.2022.2119994 |
| Makale Linki | https://www.tandfonline.com/doi/epdf/10.1080/01480545.2022.2119994?needAccess=true |
| Atıf Sayıları | |
| WoS | 2 |
