| Yazarlar (8) |
Veysel Çomaklı
Ağrı İbrahim Çeçen Üniversitesi, Türkiye |
|
İmdat Aygül
Türkiye |
|
Rüya Sağlamtaş
Türkiye |
Prof. Dr. Müslüm KUZU
Karabük Üniversitesi, Türkiye |
|
Ramazan Demirdağ
Ağrı İbrahim Çeçen Üniversitesi, Türkiye |
|
Hülya Akıncıoğlu
Türkiye |
|
Şevki Adem
Çankırı Karatekin Üniversitesi, Türkiye |
|
İlhami Gülçin
Atatürk Üniversitesi, Türkiye |
| Özet |
| This study aimed to determine the and effects of some natural and synthetic molecules on acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and α-glucosidase enzymes. Alzheimer's disease (AD) and Type II diabetes mellitus (T2DM) are considered the most important diseases of today's world. However, the side effects of therapeutic agents used in both diseases limit their use. Therefore, developing drugs with high therapeutic efficacy and better pharmacological profile is important. This study sets out to determine the related enzyme inhibitors used in treating AD and T2DM, considered amongst the most important diseases of today's world. In the current study, the and effects of dienestrol, hesperetin, Lthyroxine, 3,3',5-Triiodo-L-thyronine (T3) and dobutamine molecules on AChE, BChE and α - glycosidase enzyme activities were investigated. All the molecules showed an inhibitory effect on the enzymes. The IC and K values of the L-Thyroxine molecule, which showed the strongest inhibition effect for the AChE enzyme, were determined as 1.71 μM and 0.83 ± 0.195 μM, respectively. In addition, dienestrol, T3, and dobutamine molecules showed a more substantial inhibition effect than tacrine. The dobutamine molecule showed the most substantial inhibition effect for the BChE enzyme, and IC and K values were determined as 1.83 μM and 0.845 ± 0.143 μM, respectively. The IC and K values for the hesperetin molecule, which showed the strongest inhibition for the α -glycosidase enzyme, were determined as 13.57 μM and 12.33 ± 2.57 μM, respectively. According to the results obtained, the molecules used in the study may be considered potential inhibitor candidates for AChE, BChE and α-glycosidase. |
| Anahtar Kelimeler |
| Alzheimer's disease | Molecular modelling | acetylcholinesterase | butyrylcholinesterase | inhibition | type II diabetes mellitus | α-glycosidase. |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | CURRENT COMPUTER-AIDED DRUG DESIGN |
| Dergi ISSN | 1573-4099 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | Türkçe |
| Basım Tarihi | 01-2024 |
| Cilt No | 20 |
| Sayı | 5 |
| Sayfalar | 441 / 451 |
| Doi Numarası | 10.2174/1573409919666230518151414 |
| Makale Linki | http://dx.doi.org/10.2174/1573409919666230518151414 |
| Atıf Sayıları | |
| WoS | 3 |
| Google Scholar | 4 |
