| Yazarlar (8) |
Ahmet Uyar
Türkiye |
|
Mustafa Cellat
Hatay Mustafa Kemal Üniversitesi, Türkiye |
|
Özgür Kanat
Türkiye |
|
Muhammed Etyemez
Kastamonu Üniversitesi, Türkiye |
|
Tuncer Kutlu
Hatay Mustafa Kemal Üniversitesi, Türkiye |
|
Mehmet Zeki Yılmaz Deveci
Türkiye |
|
İlker Yavaş
Türkiye |
Prof. Dr. Müslüm KUZU
Karabük Üniversitesi, Türkiye |
| Özet |
| Bisphenol AF (BPAF) is an endocrine disruptor, and human exposure to these chemicals is growing in industrialized nations. BPAF has been demonstrated in studies to have toxic effects on reproductive health. This study examined the effects of oral exposure to BPAF on the reproductive system and the protective effects of carvacrol in rats. From 32 Wistar albino rats, four separate groups were set up for this purpose. Carvacrol 75 mg/kg and BPAF 200 mg/kg were administered by oral gavage method. Rat sperm parameters and serum testosterone levels were measured after 28 days of administration. The study looked at the MDA in the testis tissues, as well as CAT, GPx, and GSH as antioxidants parameters, NF-κB and TNF-α as inflammatory markers, caspase-3 and Bcl-2 as apoptosis parameters, and PCNA as cell proliferation markers. In addition, testis tissues underwent histological evaluation. As a result, in rats exposed to only BPAF, sperm counts declined, testosterone levels reduced, oxidative stress, inflammation, and apoptosis increased, and cell proliferation decreased. Furthermore, severe disruptions in tissue architecture and decreased spermatogenesis were reported. In contrast, sperm parameters improved, testosterone levels increased, oxidative stress and inflammation decreased, and apoptosis was prevented in the carvacrol-treated group compared to the BPAF-only group. It was also found that spermatogenesis was maintained, and structural abnormalities in testicular tissue were mostly avoided with an increase in PCNA expression. According to the findings, despite BPAF-induced testicular and reproductive toxicity, carvacrol had therapeutic potential due to its anti-inflammatory, antioxidant, cell proliferation-increasing, and anti-apoptotic activities. |
| Anahtar Kelimeler |
| Antioxidant | Apoptosis | Bisphenol AF | Carvacrol | Infertility | Inflammation |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | REPRODUCTIVE TOXICOLOGY |
| Dergi ISSN | 0890-6238 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | Türkçe |
| Basım Tarihi | 10-2023 |
| Cilt No | 121 |
| Sayı | 108456 |
| Doi Numarası | 10.1016/j.reprotox.2023.108456 |
| Makale Linki | http://dx.doi.org/10.1016/j.reprotox.2023.108456 |
| Atıf Sayıları | |
| WoS | 8 |
| Google Scholar | 8 |
