| Yazarlar (2) |
Dr. Öğr. Üyesi Ümit YILMAZ
Karabük Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Mehmet DEMİR
Karabük Üniversitesi, Türkiye |
| Özet |
| Objective: Cryptotanshinone (CTS) is a compound with anti-inflammatory, anti-bacterial, anti-oxidative and anti-aggregant functions. We aimed to determine the effects of CTS on α-naphtilthiourea (ANTU)-induced acute pulmonary edema. Materials and Methods: In this study, 4 groups (control, sham, ANTU and ANTU+CTS) were established from a total of 40 rats. The ANTU+CTS group received intraperitoneal CTS for seven days, and both ANTU and ANTU+CTS received an ANTU administration for the induction of peripheral effusion. Four hours after the ANTU administration, the rats were subjected to a forced swim test and were decapitated. Swimming times of rats, amount of pleural effusion (PE), lung weight (LW)/body weight (BW), and PE/BW ratios were determined. Results: At the end of the experiment, PE was not detected in the lungs of control and sham group rats. It was determined that PE, LW/BW and PE/BW were significantly decreased, while swimming time was increased after acute pulmonary edema in the CTS group (p<0.05). Conclusion: CTS showed a protective effect against acute pulmonary edema, which indicates that it may be used as a new therapeutic agent against pulmonary toxicity. |
| Anahtar Kelimeler |
| Cryptotanshinone | alpha-naphthylthiourea | pulmonary edema | pleural effusion | swimming duration |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | ESCI dergilerinde yayımlanan tam makale |
| Dergi Adı | Experimed |
| Dergi ISSN | 2667-5846 |
| Dergi Tarandığı Indeksler | TR DİZİN |
| Makale Dili | Türkçe |
| Basım Tarihi | 08-2023 |
| Cilt No | 13 |
| Sayı | 2 |
| Sayfalar | 121 / 126 |
| Doi Numarası | 10.26650/experimed.1308908 |
| Makale Linki | http://dx.doi.org/10.26650/experimed.1308908 |
| Atıf Sayıları |
