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Serum relaxin-3 and galanin levels in individuals with erectile dysfunction with and without type 2 diabetes mellitus   
Yazarlar (3)
Dr. Öğr. Üyesi Ümit YILMAZ Dr. Öğr. Üyesi Ümit YILMAZ
Karabük Üniversitesi, Türkiye
Dr. Öğr. Üyesi Salih BÜRLUKKARA Dr. Öğr. Üyesi Salih BÜRLUKKARA
Türkiye
Demirhan Örsan Demir
Türkiye
Devamını Göster
Özet
This study was designed to determine the serum relaxin-3 and galanin levels in individuals with erectile dysfunction with and without type 2 diabetes mellitus (T2DM). A total of 154 individuals aged 30-60 were included in the study and the participants were divided into three groups: D-ED group (individuals with T2DM and ED) (n=49), ND-ED group (individuals with ED without T2DM) (n=55), and control group (individuals without T2DM and ED) (n=50). The age, BMI, and IIEF-5 score were recorded for all participants. The HDL, LDL, triglycerides, cholesterol, HbA1c and testosterone were determined from the blood taken from the participants, and galanin and relaxin-3 levels were measured in serum samples by ELISA method. The IIEF-5 score of the D-ED group was statistically lower than that of the ND-ED and control groups, and the IIEF-5 score of the ND-ED group was also lower than that of the control group. Serum testosterone levels in the control group were statistically higher than in the D-ED and ND-ED groups. The galanin level of the D-ED group was elevated than the control and ND-ED groups, but the galanin level of the ND-ED group was lower than the control group. The relaxin-3 levels were decreased in the D-ED and ND-ED groups compared to the control group. Galanin levels increased in individuals with T2DM and ED, however decreased in individuals with ED without T2DM. In addition, reduced relaxin-3 level may play a role in the development of ED.
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayımlanan tam makale
Dergi Adı Medicine Science | International Medical Journal
Dergi ISSN 2147-0634
Dergi Tarandığı Indeksler TR DİZİN
Makale Dili İngilizce
Basım Tarihi 09-2024
Cilt No 13
Sayı 3
Sayfalar 661 / 666
Doi Numarası 10.5455/medscience.2024.07.077
Makale Linki https://doi.org/10.5455/medscience.2024.07.077