Can Juniperus communis L. oil improve nephropathy in diabetic rats
Yazarlar (6)
Prof. Dr. Tahir KAHRAMAN
Karabük Üniversitesi, Türkiye
Van Yüzüncü Yıl Üniversitesi, Türkiye
Van Yüzüncü Yıl Üniversitesi, Türkiye
Mersin Üniversitesi, Türkiye
Mersin Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | ESCI dergilerinde yayınlanan tam makale |
| Dergi Adı | Clinical and Experimental Health Sciences |
| Dergi ISSN | 2459-1459 Wos Dergi |
| Dergi Tarandığı Indeksler | ESCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 06-2020 |
| Cilt No | 10 |
| Sayı | 2 |
| Sayfalar | 120 / 124 |
| DOI Numarası | 10.33808/clinexphealthsci.543272 |
| Makale Linki | https://dergipark.org.tr/tr/pub/marusbed/issue/54992/543272 |
| Özet |
| Objective: Juniperus communis L. (J. communis) is a shrub belonging to family Cupressaceae L. mainly growth in Eurasia. The antioxidant andantidiabetic activity of aqueous extract of J. communis L. berries indicated benefits as a potent antidiabetic in streptozotocin induced diabeticalbino rats. This study was carried out to determine whether J. communis L. oil supplement will effectively manage renal dysfunction in diabeticrats.Methods: Twenty eight rats were divided into 4 equal groups as follows; control group, diabetic group (45 mg/kg, i.p. streptozotocin) , J.communis L. oil (200 mg/kg) treated group, and diabetic+J. communis L. oil (200 mg/kg) treated group. At the end of the experimental period,all rats were sacrificed and renal function parameters such as kidney antioxidant and lipid peroxidation markers and serum glucose, HbA1c,creatinine, serum urea, blood urea nitrogen (BUN), and serum total protein levels were measured in all groups.Results: HbA1c, serum glucose, urea, creatinine, BUN and, kidney lipid peroxidation levels increased (p<0.05), but serum total protein andantioxidant levels decreased in diabetic group comparing with control group (p<0.05). Furthermore, HbA1c, serum glucose, urea, creatinineand BUN and, kidney lipid peroxidation levels decreased and also, serum total protein and antioxidant levels increased in diabetic group treatedwith J. communis L. oil comparing with diabetic group (p<0.05).Conclusion: This study has provided that J. communis L. oil provide a protective effect on the kidney as evidenced by an improvement of therenal function tests as well as reduction in oxidative stress parameters in experimental diabetic nephropathy model. |
| Anahtar Kelimeler |
| Juniperus communis L. | diabetes | nephropathy | antioxidant | lipid peroxidation | oxidative stress |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 1 |
| Google Scholar | 2 |