| Yazarlar (3) |
Emre Taskin
|
|
Hasan Bagci
|
Doç. Dr. Muhammed Kamil TURAN
Karabük Üniversitesi |
| Özet |
| The aim of this study was to determine frequency and associations between APOA5 c.56C>G, -1131T>C, c.553G>T, and APOC3 -482C>T and SstI gene polymorphisms with hypertriglyceridemia. Under a case-control study model, 135 hypertriglyceridemic and 178 normotriglyceridemic control participants were recruited. Polymerase chain reaction and restriction fragment length polymorphism methods were utilized for genotyping. Statistical calculations were performed by comparing allele and genotype frequencies between groups. Clinical characteristics were compared between groups and intra-group genotypes. APOC3 gene -482C>T and SstI polymorphic genotypes and allele frequencies were significantly higher in hypertriglyceridemic group (genotype frequencies, p=0.035, p=0.028, respectively). Regression analysis under unadjusted model confirmed that APOC3 -482C>T and SstI polymorphisms were significantly contributing to have hypertriglyceridemia (p=0.02, odds ratio [OR]=1.831 (95% confidence interval [CI] 1.095-3.060); p=0.04, OR=1.812 (1.031-3.183), respectively). APOA5 c.56C>G was in complete linkage disequilibrium with APOA5 c.553G>T polymorphism (D'=1). For the first time in a population sample from Turkey, among the five polymorphisms of APOA5 and APOC3 genes investigated, APOC3 -482C>T and SstI polymorphisms were associated with elevated serum TG levels, while APOA5 c.56C>G, -1131T>C, and c.553G>T polymorphisms were not. |
| Anahtar Kelimeler |
| Apolipoprotein | A-V | Apolipoprotein C-III | Lipids | Apolipoproteins | Genetic variation |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | REVISTA DA ASSOCIACAO MEDICA BRASILEIRA |
| Dergi ISSN | 0104-4230 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | Türkçe |
| Basım Tarihi | 01-2023 |
| Cilt No | 69 |
| Sayı | 3 |
| Sayfalar | 415 / 420 |
| Doi Numarası | 10.1590/1806-9282.20221016 |
| Makale Linki | http://dx.doi.org/10.1590/1806-9282.20221016 |
| Atıf Sayıları | |
| WoS | 2 |
| Google Scholar | 2 |
