Utilizing linkage-specific ethyl-esterification approach to perform in-depth analysis of sialylated N-glycans present on milk whey glycoproteins
Yazarlar (9)
Doç. Dr. Hacı Mehmet KAYILI Karabük Üniversitesi, Türkiye
Nazire Barlas
Hacettepe Üniversitesi, Türkiye
Hacettepe Üniversitesi, Türkiye
Deniz Baran Demirhan
Karabük Üniversitesi, Türkiye
Karabük Üniversitesi, Türkiye
Doç. Dr. Mehmet Emrah Yaman Atatürk Üniversitesi, Türkiye
Doç. Dr. Mehmet Atakay Hacettepe Üniversitesi, Türkiye
Dr. Öğr. Üyesi Ülkü Güler Tokat Hacettepe Üniversitesi, Türkiye
Prof. Dr. Mustafa Kara Atatürk Üniversitesi, Türkiye
Prof. Dr. Kadir Şerafettin Tekgündüz Ataturk University, Faculty Of Medicine, Türkiye
Prof. Dr. Bekir Salih Hacettepe Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Food Chemistry (Q1) | ||
| Dergi ISSN | 0308-8146 Dergi Bilgileri (2023) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 09-2023 |
| Cilt / Sayı / Sayfa | 421 / 1 / 136166–0 | DOI | 10.1016/j.foodchem.2023.136166 |
| Makale Linki | http://dx.doi.org/10.1016/j.foodchem.2023.136166 | ||
| UAK Araştırma Alanları |
Analitik Kimya
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| Özet |
| Glycosylation of milk whey proteins, specifically the presence of sialic acid-containing glycan residues, causes functional changes in these proteins. This study aimed to analyze the N-glycome of milk whey glycoproteins from various milk sources using a linkage-specific ethyl esterification approach with MALDI-MS (matrix-assisted laser desorption/ionization-mass spectrometry). The results showed that the N-glycan profiles of bovine and buffalo whey mostly overlapped. Acetylated N-glycans were only detected in donkey milk whey at a rate of 16.06%. a2,6-linked N-Acetylneuraminic acid (a2,6-linked NeuAc, E) was found to be the predominant sialylation type in human milk whey (65.16%). The amount of a2,6-linked NeuAc in bovine, buffalo, goat, and donkey whey glycoproteomes was 42.33%, 44.16%, 39.00%, and 34.86%, respectively. The relative abundances of a2,6-linked N-Glycolylneuraminic acid (a2,6 … |
| Anahtar Kelimeler |
| Ethyl-esterification | Glycomics | MALDI-MS | Milk | N-glycans | Whey glycoproteins |
Science Direct
Utilizing linkage-specific ethyl-esterification approach to perform in-depth analysis of sialylated N-glycans present on milk whey glycoproteins
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 3 |
| Scopus | 4 |
| Google Scholar | 5 |