Titanium dioxide-induced fibrotic liver model and the therapeutic effect of resveratrol by modulation of α-SMA and 8-oHdG expressions, oxidative stress, and inflammation
Yazarlar (4)
Doç. Dr. Feyza BAŞAK Karabük Üniversitesi, Türkiye
Dr. Öğr. Üyesi Tansu KUŞAT Karabük Üniversitesi, Türkiye
Dr. Öğr. Üyesi Yusuf ERSAN Karabük Üniversitesi, Türkiye
Prof. Dr. Tahir KAHRAMAN Karabük Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Tissue and Cell (Q1) | ||
| Dergi ISSN | 0040-8166 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2025 |
| Cilt / Sayı / Sayfa | 93 / 1 / 102748–0 | DOI | 10.1016/j.tice.2025.102748 |
| Makale Linki | https://doi.org/10.1016/j.tice.2025.102748 | ||
| UAK Araştırma Alanları |
Tıbbi Biyokimya
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| Özet |
| The research sought to assess the therapeutic impact of resveratrol by biochemical, immunohistochemical, and histopathological analyses in a TiO2-induced liver fibrosis model. Titanium dioxide (100 mg/kg body weight) was delivered for 15 days to induce liver fibrosis, either alone or in conjunction with resveratrol (30 mg/kg body weight) therapy for the same duration. Resveratrol has been identified as a crucial therapeutic drug that provides an alternative treatment method for TiO2-induced liver fibrosis by mitigating inflammation, oxidative stress, and the expressions of α-SMA and 8-OHdG. Resveratrol treatment mitigated TiO2-induced liver fibrosis by repairing hepatocellular injury and decreasing plasma AST, ALT, and ALP levels. Resveratrol improves the activity of superoxide dismutase (SOD) and catalase (CAT), crucial enzymes for antioxidant defense, and elevates glutathione peroxidase (GSH-Px) levels … |
| Anahtar Kelimeler |
| 8-OHdG | Inflammation | Liver fibrosis | Oxidative stress | Resveratrol | TiO2 | α- SMA |
Science Direct
Titanium dioxide-induced fibrotic liver model and the therapeutic effect of resveratrol by modulation of α-SMA and 8-oHdG expressions, oxidative stress, and inflammation
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 7 |
| Scopus | 7 |
| Google Scholar | 10 |