Synthesis and anti-cancer properties of Pd(II) and Pt(II) coordination compounds of heterocyclic Schiff base ligands
Yazarlar (3)
Mustafa Al-Azzawı Karabük Üniversitesi, Türkiye
Doç. Dr. İsmail YILMAZ Karabük Üniversitesi, Türkiye
Dr. Öğr. Üyesi Hayrani Eren Bostancı Cumhuriyet Üniversitesi, Türkiye
Makale Türü Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı Journal of Molecular Structure (Q2)
Dergi ISSN 0022-2860 Dergi Bilgileri (2025)
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili Türkçe Basım Tarihi 08-2025
Cilt / Sayı / Sayfa 1337 / 1 / – DOI 10.1016/j.molstruc.2025.142199
Makale Linki https://doi.org/10.1016/j.molstruc.2025.142199
UAK Araştırma Alanları
Anorganik Kimya
Özet
In this study, three heterocyclic Schiff base ligands (LH) were synthesized through the reaction of 2-aminomethyl thiophene, 2-aminomethyl pyridine, and 2-aminomethyl piperidine amines with 2-hydroxybenzaldehyde. Subsequently, their corresponding metal complexes with platinum(II) and palladium(II) salts were prepared. The ligands act monoanionic, coordinating to the metal center through the O atom of the phenol and N atom of the imine, forming a neutral bis-chelating square-planar complex [ML2]. The ligands and their related Pd(II) and Pt(II) complexes were characterized using FT-IR, 1H NMR, 13C NMR, and mass spectrometry. Additionally, the structure of the C1 complex was elucidated through single-crystal X-ray analysis. When the biological activities of the synthesized compounds were examined, it was found that compound C1 was more efficient than cisplatin in killing breast cancer cells with an IC50 dose (31.80 ± 4.05 µM) as a result of MTT studies. The results obtained in flow cytometry studies coincide with these data. In the antioxidant studies obtained using the FRAP method, it was determined that the synthesized compounds did not have any antioxidant power.
Anahtar Kelimeler
Anti-cancer activity | Antioxidant | Flow cytometry | Palladium(II) complex | Platinum(II) complex | Schiff base ligands