Application of central composite design for the optimization of electrode surface composition for glucose biosensor fabrication
Yazarlar (4)
Doç. Dr. İrem OKMAN KOÇOĞLU Karabük Üniversitesi, Türkiye
Pınar Esra Erden Ankara Hacı Bayram Veli Üniversitesi, Türkiye
Adnan Kenar
Ankara Üniversitesi, Türkiye
Ankara Üniversitesi, Türkiye
Esma Kılıç Ankara Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Analytical and Bioanalytical Chemistry (Q1) | ||
| Dergi ISSN | 1618-2642 Dergi Bilgileri (2019) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2019 |
| Cilt / Sayı / Sayfa | 411 / 2 / 413–425 | DOI | 10.1007/s00216-018-1454-3 |
| Makale Linki | https://doi.org/10.1007/s00216-018-1454-3 | ||
| UAK Araştırma Alanları |
Analitik Kimya
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| Özet |
| The use of a central composite design (CCD) for the optimization of electrode surface composition and its application to develop an amperometric glucose biosensor as a model system are described. A five-level three-factorial CCD was applied to determine the optimum electrode surface composition for three critical variables: amounts of carboxylated multiwall carbon nanotubes (c-MWCNT), titanium dioxide nanoparticles (TiO 2 NP), and glucose oxidase (GOx). The statistical significance of the model and factors were evaluated using the variance analysis (ANOVA) at 95% of confidence level. The optimized electrode surface composition was used for the fabrication of the glucose biosensor. The resulting biosensor showed linear response to glucose from 2.0× 10− 5 to 1.9× 10− 3 M with a detection limit of 2.1× 10− 6 M and sensitivity of 168.5 μA mM− 1 cm− 2 under optimal experimental conditions. Analytical … |
| Anahtar Kelimeler |
| Carbon nanotube | Central composite design | Glucose biosensor | Titanium dioxide nanoparticles |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 13 |
| Scopus | 16 |
| Google Scholar | 21 |