Investigation of cytotoxicity and genotoxicity properties of modified hemp fiber filled PLA biocomposites
Yazarlar (6)
Dr. Öğr. Üyesi Nurhan ÇEVİK ELEN Karabük Üniversitesi, Türkiye
Doç. Dr. Bünyamin Çiçek Hitit University, Türkiye
Doç. Dr. Levent ELEN Karabük Üniversitesi, Türkiye
Öğr. Gör. Büşra Moran Hitit University, Türkiye
Doç. Dr. Musa YILDIRIM Karabük Üniversitesi, Türkiye
Prof. Dr. Yasin KANBUR Karabük Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine (Q4) | ||
| Dergi ISSN | 0954-4119 Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 07-2025 |
| Cilt / Sayı / Sayfa | 239 / 7 / 697–705 | DOI | 10.1177/09544119251351717 |
| Makale Linki | https://doi.org/10.1177/09544119251351717 | ||
| UAK Araştırma Alanları |
Polimer Bilimi
Fiziksel Kimya
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| Özet |
| This study aimed to investigate the biocompatibility and toxicity of biodegradable composites reinforced with hemp fibers in a polylactic acid (PLA) matrix. To enhance the compatibility of hemp fibers with PLA, various polymer structures, including maleic anhydride (MA), polybutylene succinate (PBS), and thermoplastic polyurethane (TPU), were incorporated. Additionally, surface modification of hemp fibers was carried out using sodium hydroxide (NaOH) and 3-(2-aminoethylamino) propyl trimethoxy silane (APTES) to improve interfacial adhesion. The in vitro biocompatibility and genotoxicity of the produced composites were evaluated using L-929 fibroblast and CHO-K1 cell lines. In the cytotoxicity tests, cells were exposed to composite extracts for 24 h, after which viability rates were determined to assess possible toxic effects. Genotoxicity tests were performed to examine potential DNA damage induced by the … |
| Anahtar Kelimeler |
| biocompatibility | Biodegradable composites | cytotoxicity | genotoxicity | hemp fibers |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 3 |
| Scopus | 3 |
| Google Scholar | 3 |