N-glycan profiling of papillary thyroid carcinoma tissues by MALDI-TOF-MS
Yazarlar (6)
Doç. Dr. Ömer Faruk Koçak Atatürk Üniversitesi, Türkiye
Doç. Dr. Hacı Mehmet KAYILI Karabük Üniversitesi, Türkiye
Prof. Dr. Mevlüt Albayrak Atatürk Üniversitesi, Türkiye
Doç. Dr. Mehmet Emrah Yaman Atatürk Üniversitesi, Türkiye
Prof. Dr. Yücel Kadıoğlu Atatürk Üniversitesi, Türkiye
Prof. Dr. Bekir Salih Hacettepe Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Analytical Biochemistry (Q2) | ||
| Dergi ISSN | 0003-2697 | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2019 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-11-2019 |
| Cilt / Sayı / Sayfa | 584 / 1 / 113389–0 | DOI | 10.1016/j.ab.2019.113389 |
| Makale Linki | http://dx.doi.org/10.1016/j.ab.2019.113389 | ||
| UAK Araştırma Alanları |
Analitik Kimya
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| Özet |
| Papillary thyroid carcinoma (PTC) is a type of thyroid cancer whose incidence rate has increased recently all over the world. Glycosylation is a crucial post-translational modification (PTM) for the regulation of thyroid hormone synthesis in thyroid glands. However, our knowledge regarding the N-glycosylation change in PTC is limited. To the best of our knowledge, this is the first study to profile glycans in PTC tissues by mass spectrometry. Herein, we have analyzed the N-glycans of formalin-fixed paraffin-embedded (FFPE) tissues of patients diagnosed with PTC in a matched case-control study. Using MALDI-TOF(/TOF)-MS, 35 enzymatically released N-glycan compositions were characterized. The statistical analyses showed significant differences including six N-glycan compositions (p < 0.001) between patients and controls. It was determined that four of them (H5N4E1, H5N4F1E1, H5N4F1L1E1 and H5N4F1E2 … |
| Anahtar Kelimeler |
| Glycomics | Glycosylation | Mass spectrometry | N-Glycans | Papillary thyroid cancer |
Science Direct
N-glycan profiling of papillary thyroid carcinoma tissues by MALDI-TOF-MS
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 23 |
| Scopus | 24 |
| Google Scholar | 29 |